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The medications listed on this website are provided for informational purposes only. Their inclusion does not guarantee that they will be prescribed to any individual, as treatment decisions are ultimately at the discretion of healthcare providers. This list is not exhaustive, and healthcare providers may prescribe other medications, including non-stimulant options, based on the patient's unique health circumstances and needs.

Often, online sites buzz with this question on the drug, Is mixing Vyvanse and alcohol safe?

Vyvanse is a central nervous system stimulant approved by the FDA for treating symptoms related to ADHD.

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Like other stimulants, drinking alcohol may result in potentially dangerous complications sometimes. 

All in all, some individuals who have experienced ugly side effects from mixing Vyvanse with alcohol have found the following suggestions helpful.

Keep reading as we give tips on how to minimize risks of Vyvanse with alcohol.

What Should You Not Mix With Vyvanse?

Even if Vyvanse is well-tolerated, sometimes long-term use can lead to:

  • Irritability
  • Low mood
  • Poor concentration
  • Insomnia

Other warnings for Vyvanse use include anxiety and depression that may lead to suicidal thoughts.

That said, there is a high likelihood that Vyvanse may react with almost any drug you ingest simultaneously.

More importantly, it would help if you considered, can you drink alcohol while on ADHD medication? Although medics discourage combining Vyvanse and alcohol, doing it right can minimize some reactions. 

Further on this, it is not uncommon to hear patients ask, can I skip Vyvanse on weekends?

The only exception from taking your daily dosage is only on exceptional occasions like a wedding. In other terms, skipping your dosage for a day or two may not do much damage.

However, some patients complain of unwanted side effects such as:

vyvanse and alcohol

Dangers of Combining Alcohol With Vyvanse

Here are some substances that you should steer off when taking Vyvanse. 

  • Depressants

Mixing Vyvanse with depressants such as alcohol, marijuana, or tranquilizers can be fatal.

Common dangers of Mixing Vyvanse and Alcohol include:

  • Racing heartbeat
  • Tremors
  • Sweating
  • Nausea

If you experience such reactions, stop using tranquilizers or alcohol immediately.

Seek medical help if the symptoms worsen or lead to chest pain, vomiting blood as it can indicate an onset of a life-threatening heart problem called cardiomyopathy.

Above all, if you have to take your favorite drink, limit it to not more than 80 ml in a night.

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  • Other Stimulants

If you have a history of mental illness such as bipolar disorder, schizophrenia, or other psychotic disorders, avoid taking Vyvanse with other prescribed drugs.

The combination has been known to cause psychosis and can result in disastrous consequences. Bear in mind that ingesting Vyvanse with other ADHD drugs can result in an overdose.

  • Drugs With Dextromethorphan 

Dextromethorphan is a component common in cough medicines.

Combining these drugs with Vyvanse has often produced strange behavior in children, such as:

  • Irritability
  • Teeth grinding
  • Excessive crying
  • Addictive Drugs

You should also avoid taking Vyvanse if you’ve recently been on a drug of addiction classified under opioids. This is a category that contains illegal drugs such as heroin. Others include fentanyl and legally prescribed pain killers like oxycodone. 

vyvanse and alcohol

Treatment Options for Addiction

Can Vyvanse Cause Sudden Death?

According to the American College of Cardiology, there is no causal relationship between Vyvanse and heart complications or sudden death with first-line stimulants approved by FDA.

Instead, some of the reported cases may be due to pre-existing heart conditions and other factors like high blood pressure or family history when used for a long time. 

Still, experts insist that if you experience chest pain, shortness of breath, or numbness in your arm or jaw, stop taking Vyvanse immediately. Most importantly, follow the doctor’s advice for safer use. 

Can You Take Vyvanse With a Hangover?

The only reason you would take Vyvanse amid a hangover is to use other drugs to treat:

  • ADHD
  • Narcolepsy
  • Sleep apnea
  • Obesity

For this reason, get your dosage right from qualified therapists to avoid other warnings for Vyvanse [1*] in the future. 

More so, some patients inquire, can you gain weight on Vyvanse

Although Vyvanse is not approved for weight loss, some expert insists that it is an effective drug in treating:

  • Binge eating disorders
  • Overeating
  • Anorexia

Mainly, it helps individuals by feeling fuller longer and reducing cravings for certain foods.

How long Does Vyvanse Take to Peak?

Research indicates that Vyvanse taken on an empty stomach begins to act within one hour in children between 6 and 12 years. The effects of this drug in adults were slightly slower at two hours and continued to build as time goes on. 

Does Vyvanse Change Your Personality?

One common reaction to this drug is that some people have a change in their personality at first.

It can lead to feeling extra suspicious, hyperactive, or experience increased interest in sex.

If you notice any one of these symptoms while on this medication, it could be a sign that your body has not adapted to the dosage and that you should switch back to lower doses to avoid getting these side effects. 

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Final Thoughts

Taking Vyvanse with alcohol can make patients feel sleepy and drowsy. This may put you at risk when driving or running heavy machinery. If you’re addicted to Vyvanse or alcohol, take action and get professional help immediately.

The quickest treatment for addiction to Vyvanse and alcohol is seeking help from qualified therapists.


+1 sources
  1. Lisdexamfetamine Dimesylate (Vyvanse), A Prodrug Stimulant for Attention-Deficit/Hyperactivity Disorder. (2010)
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This article is based on scientific evidence, written by experts and fact checked by experts.

Our team of experts strive to be objective, unbiased, honest and to present both sides of the argument.

This article contains scientific references. The numbers
in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.